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The Rappaport Institute looks forward to continuing to make substantial future contributions in biomedical research"

Professor Karl Skorecki

BioRap and BioTheryX Sign Strategic Collaborative Agreement for the Development of Novel Protein Degradation Compounds for the Treatment of Cancer and Immune Disorders

8 September, 2016

BioRap and BioTheryX Sign Strategic Collaborative Agreement for the Development of Novel Protein Degradation Compounds for the Treatment of Cancer and Immune Disorders


San Diego, CA, September 8, 2016 – BioTheryX, Inc. (BTX), is developing next-generation drugs that selectively regulate the stability of disease-causing proteins to treat a broad range of diseases, including cancer and immune disorders.  BioTheryX’s innovative approach to drug discovery exploits the exquisite specificity of the ubiquitin proteasome system (UPS).  BioTheryX has entered into a strategic collaboration with Nobel laureate Dr. Aaron Ciechanover at the Rappaport Institute to employ advanced ubiquitin-directed proteomics to assist in elucidating direct protein targets and prognostic biomarkers for BTX’s proprietary small molecule Protein Homeostatic Modulators (PHMs).  This powerful new class of small molecule drugs will selectively modulate key therapeutically validated protein targets in oncology, immunology, inflammation, as well as emerging targets in the fields of immune-oncology and cancer stem cells.  Dr. Ciechanover is a Distinguished Research Professor at the Rappaport institute for Biomedical Research-Technion-Israel Institute of Technology, and BioRap Technologies is its technology transfer arm.  Professor Ciechanover, together with colleagues Drs. Avram Hershko and Irwin Rose, won the 2004 Nobel Prize in chemistry for the discovery of ubiquitin mediated protein degradation. Along with Hershko, he was also recognized with the prestigious Albert Lasker Award for Basic Medical Research (2000).  Additionally, among many world renowned organizations, Dr. Ciechanover is a member of the USA National Academies of Sciences (NAS) and Medicine (NAM). 

The BioTheryX team, led by Celgene Corp. founder David Stirling, were the developers of the remarkable IMiDs™ family of compounds while at Celgene.  It is now known that the IMiDs (a franchise of blood cancer compounds now exceeding $35 billion) work by promoting ubiquitin degradation of key protein targets in oncology, giving the BTX team the most commercial experience in the protein regulation field.

David Stirling, Chief Executive Officer, BioTheryX, commented, “BioTheryX is pleased and excited to be working with Professor Ciechanover, the “father” of the ubiquitin-proteasome field, to advance these exciting compounds into the clinic.  Our proprietary PHMs are orally available, small molecule compounds which display potent and selective biological activities and excellent safety profiles.  We believe BTX’s PHMs will have clinical utility in both cancer and immune disorders.  Indeed, the lead compound in this series promotes selective degradation of a well-documented, clinically validated drug target more effectively than currently approved drugs, and this trajectory could represent a significant fast track to the clinic.”

Professor Aaron Ciechanover, Tumor and Vascular Biology Research Center, The Rappaport Faculty of Medicine and Research Institute, Technion-Israel Institute of Technology, commented, “The platform discovered by BioTheryX is exciting and broad, and can be applied to any substrate at will.  It opens a wide window to the development of novel therapeutic modalities to a broad array of diseases, including malignancies and neurodegenerative disorders.  Therefore, we are excited to be part of this novel and promising emerging approach”

About BioTheryX

BioTheryX, Inc., founded by the drug development team behind the remarkable IMiDs™ franchise of compounds which have improved the quality of life of so many cancer patients and their loved ones, is applying its extensive and proven commercial success to deliver efficacious therapies to patients with unmet medical needs.  The team’s core expertise is to discover and develop molecules that regulate protein homeostasis and stimulate the immune system to destroy cancers with minimal toxicities by utilizing enhanced biology-driven models.  As a result, these novel drug candidates have large therapeutic windows.  When coupled with clinically proven translational therapeutics targeting cancer and immune dysregulation, the result is a rapid delivery of new drugs to patients with unmet medical needs.  For more information please visit

About BioRap
BioRap is the Rappaport Institute's technology transfer company led by Dr Orit Shaked and its liaison to industry, bringing promising scientific innovations generated at the Institute to collaboration with industry and commercialization. The company provides the legal and commercial frameworks for the inventions and innovations of RI researchers, protecting discoveries and innovations with patents, and working jointly with industry to bring scientific discovery to the market. For more information, visit

Media Contact for BioRap

Orit Shaked, Biorap Technologies, Rappaport Research Institute

Tel: +972 (0)4829-5402

Mob: +972 (0)5476 52313




Media Contact for BioTheryX

Lawrence Zaslow, President

BioTheryX, Inc.

Tel:  (914)-490-5425


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